Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)- Quinazolinone Derivatives
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چکیده
منابع مشابه
Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)-Quinazolinone Derivatives
Heterocyclic scaffold has been under discovery due to their considerable therapeutic and medicinal importance. One of such heterocycles 2-pyrimidinone, while not naturally occurring, are receiving increased attention because of their wide-ranging biological activity like, an efficient inhibitor of DNA synthesis in E. coli, inhibitors of the enzyme cytidinedeaminase, and as metaphase inhibitors....
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Heterocyclic scaffold including nitrogen, sulfur and oxygen has been under exploration due to their significant therapeutic and medicinal properties. Among these types of molecules, 4thiazolidinones have displayed various important biological activities. Especially rhodanine (2-thioxothiazolidine-4-ones) derivatives represent privileged scaffolds in drug discovery, due to the presence of >N–C–S...
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Starting from 6-aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (4a-d), a series of mono- and dialkyl derivatives 5a-j and 6a, b was synthesized. Hydrazinolysis of 4a, b, d and 5d afforded the hydrazino derivatives 7a-c which were cyclised to give the triazolopyrimidinones 8a-c and the pyrimidotriazinones 9a-c through the reaction with formic acid and chloroacetyl chloride, resp...
متن کاملSynthesis of Some New Quinazolinone Derivatives and Evaluation of Their Antimicrobial Activities
Wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. Deoxyvasicinone which wa...
متن کاملSynthesis of Some New Quinazolinone Derivatives and Evaluation of Their Antimicrobial Activities
Wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. Deoxyvasicinone which wa...
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ژورنال
عنوان ژورنال: Organic Chemistry: Current Research
سال: 2013
ISSN: 2161-0401
DOI: 10.4172/2161-0401.1000118